Mayhew I G
Vet Pathol. 1984 Mar;21(2):187-92. doi: 10.1177/030098588402100210.
Arthrogryposis multiplex congenita was studied in a newborn thoroughbred foal. The syndrome affected only the left hind limb allowing the right hind limb to serve as a reference. There was a significant depletion of large motor neurons from the ventral horn of the spinal cord from L3 to S4 on the affected side. Hypoplasia of nerves, muscles, and bones was present in the affected limb. Histologically, hypoplasia and degeneration of myofibers and nerve bundles were seen. No cause of the syndrome, which corresponds to most human cases, was determined. Neuromuscular arthrogryposis was diagnosed because of the difficulty in distinguishing primary neuropathic from primary myopathic forms of the disease.
对一匹新生纯种马驹进行了先天性多发性关节挛缩症的研究。该综合征仅影响左后肢，右后肢可作为对照。患侧脊髓腰3至骶4腹角的大型运动神经元明显减少。患侧肢体存在神经、肌肉和骨骼发育不全。组织学检查可见肌纤维和神经束发育不全及变性。未确定该综合征（与大多数人类病例相符）的病因。由于难以区分该疾病的原发性神经病变型和原发性肌病变型，故诊断为神经肌肉性关节挛缩症。
