Vetter J, Mikus E, Müller T, Morgenstern R, Wehner W, Franke T
Z Exp Chir Transplant Kunstliche Organe. 1984;17(2):126-36.
Liver cuts were performed on 21 Mini- Lewe pigs and then closed with suture in one case, and by ultrasonic welding of Fimomed - Gelaspon conglomerate in the other. Macroscopic assessment in situ and the histological examination of cut out liver areas regularly showed perifocal inflammatory peritoneal reactions and abscess formation for the sutured regions. From a histological point of view the liver tissue in the regions subjected to ultrasonic treatment reacted more strongly than after suture, particularly in the form of lobule structure disturbances, focal hepatitis, hepatic duct proliferation and destruction, and cholangitis. All of these were limited to the immediate vicinity of the conglomerate with its fibrous demarcation, which remained identifiable until the end of the experiment after a year and a half. The experiments resulted in the sucessful closure of the liver wounds in all cases where ultrasonic welding of Fimomed - Gelaspon compound was used. Application to human medicine is, however, not yet justified.
对21只小型猪进行肝脏切割，其中1例用缝线缝合肝脏切口，另1例用Fimomed - Gelaspon聚合体进行超声焊接。原位宏观评估和切除肝脏区域的组织学检查结果显示，缝合区域经常出现灶周炎性腹膜反应和脓肿形成。从组织学角度来看，接受超声治疗区域的肝组织反应比缝合后更强烈，尤其是表现为小叶结构紊乱、局灶性肝炎、肝管增生和破坏以及胆管炎。所有这些都局限于聚合体及其纤维分界的紧邻区域，在实验进行了一年半直至结束时仍可识别。实验结果表明，在所有使用Fimomed - Gelaspon复合物进行超声焊接的病例中，肝脏伤口均成功闭合。然而，目前将其应用于人类医学尚不合理。
