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儿童炎症性肠病——治疗与随访

Inflammatory bowel disease in childhood--treatment and follow up.

作者信息

Krebs C, Nixon H H

出版信息

Z Kinderchir. 1984 Feb;39(1):29-34. doi: 10.1055/s-2008-1044165.

Abstract

This study is based on 150 patients whose first symptoms of inflammatory bowel disease (IBD) appeared before puberty between 1955 and 1979. Recurrence of disease after improvement on medical treatment occurred within a shorter time in Crohn's disease than in ulcerative colitis. In this series it was twice as probable for surgery to be required within the first five years of illness for a child with Crohn's disease than for a child with ulcerative colitis. Median relapse time after medical treatment was 11 months for ulcerative colitis and 15 months for Crohn's disease, and the median relapse time after surgical treatment (including "incomplete" procedures) was over seven years for ulcerative colitis and just under five years for Crohn's disease. In ulcerative colitis it is suggested that earlier surgery might save the patient a period of distressing symptoms and reduce the risk of recurrence.

摘要

本研究基于150例炎症性肠病(IBD)首发症状出现在1955年至1979年青春期前的患者。药物治疗病情改善后,克罗恩病的复发时间比溃疡性结肠炎短。在这个系列中,患有克罗恩病的儿童在患病的头五年内比患有溃疡性结肠炎的儿童需要手术的可能性高两倍。溃疡性结肠炎药物治疗后的中位复发时间为11个月,克罗恩病为15个月,溃疡性结肠炎手术治疗(包括“不完全”手术)后的中位复发时间超过7年,克罗恩病略低于5年。对于溃疡性结肠炎,建议早期手术可能使患者免于一段痛苦的症状期,并降低复发风险。

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