Saul W, Willberg B, Bremer H J
Z Kinderchir. 1984 Apr;39(2):96-8. doi: 10.1055/s-2008-1044183.
Whereas today intensive-paediatric management of the acute, life-threatening situation in organically conditioned hypoglycaemias is quite successful, conservative long-term treatment of nesidioblastosis is still unsatisfactory with regard to the prevention of subsequent cerebral damage. In contrast, subtotal pancreatectomy as performed by us is a curative treatment. Chances of cure are of course greatest if the treatment is effected before the onset of secondary damage. This is demonstrated by means of the authors' own patient material which comprises 10 surgically treated children with nesidioblastosis. Three of four infants operated on during the first weeks of their lives became normoglycaemic after the operation and developed normally, whereas only two of the six remaining children operated on at a later stage in their lives showed a comparably good course of the disease. The criteria of the surgical indication, surgical mode of procedure, intraoperative and postoperative complications and results obtained by the authors, are presented.
虽然如今对于器质性低血糖症急性危及生命情况的强化儿科管理相当成功，但就预防随后的脑损伤而言，持续性高胰岛素血症的保守长期治疗仍不尽人意。相比之下，我们所实施的胰腺次全切除术是一种治愈性治疗方法。当然，如果在继发性损伤发生之前进行治疗，治愈的机会最大。作者自己的患者资料证明了这一点，该资料包含10名接受手术治疗的持续性高胰岛素血症儿童。在出生后第一周内接受手术的4名婴儿中，有3名术后血糖恢复正常且发育正常，而其余6名在生命后期接受手术的儿童中，只有2名显示出类似的良好病程。文中介绍了手术指征的标准、手术操作方式、术中和术后并发症以及作者所取得的结果。
