Johnson W J, O'Brien P C
Nephron. 1978;21(3):123-30. doi: 10.1159/000181382.
Two formulations of aluminum phosphate binders-aluminum hydroxide suspension and aluminum carbonate powder in the form of capsules-were found to be equally effective in lowering the plasma phosphate concentration. The effective dose was 4 g/day given in divided doses before meals and at bedtime. Side effects were negligible with this dosage for both preparations, but aluminum carbonate capsules were preferred by most patients because of the greater convenience of the capsule form. Coincident with the lowering of serum phosphorus concentrations, serum parathyroid hormone concentrations decreased approximately 30% from levels obtained while patients were taking placebo.
两种磷酸铝结合剂制剂——氢氧化铝混悬液和胶囊形式的碳酸铝粉末——在降低血浆磷酸盐浓度方面被发现同样有效。有效剂量为每日4克，分剂量在饭前和睡前服用。两种制剂采用此剂量时副作用可忽略不计，但大多数患者更喜欢碳酸铝胶囊，因为胶囊形式更方便。与血清磷浓度降低同时发生的是，血清甲状旁腺激素浓度较患者服用安慰剂时测得的水平下降了约30%。
