Matsumura H, Setoguti T, Mori K, Ross E R, Koto A
Acta Pathol Jpn. 1984 Jan;34(1):1-9. doi: 10.1111/j.1440-1827.1984.tb02176.x.
In studying three human intracranial germinomas tubuloreticular structures were observed within the cisterns of granular endoplasmic reticulum (RER), as well as occasionally within dilated perinuclear spaces of capillary endothelial cells. These tubuloreticular structures seen as a network of branching, convoluted, tubular profiles appear to originate from amorphous material. The development of these structures could be classified into three stages. In Stage I, the precursor substance appears as dense amorphous material within the cisterns of RER. Stage II is marked by the transformation of the amorphous material to coarse particulate material which aggregates to form tubular units. During the first and second stages, the distended RER that participates in the formation of these structures is accompanied by numerous attached ribosomes and is closely associated with mitochondria. In Stage III, the tubular units fuse with one another to form the tubuloreticular structure. In this third stage both ribosomes and mitochondria are almost absent. As a result of the almost complete disappearance of these organelles at this time, both the attached ribosomes and mitochondria may play an important role in the synthesis of the precursor substance as well as in its transformation to the tubuloreticular structure.
在研究三例人类颅内生殖细胞瘤时，在粗面内质网（RER）池内观察到管状网状结构，偶尔也在毛细血管内皮细胞扩张的核周间隙内观察到。这些管状网状结构表现为分支、盘绕的管状轮廓网络，似乎起源于无定形物质。这些结构的形成可分为三个阶段。在第一阶段，前体物质表现为RER池内的致密无定形物质。第二阶段的特征是无定形物质转变为粗颗粒物质，这些颗粒聚集形成管状单元。在第一和第二阶段，参与这些结构形成的扩张RER伴有大量附着的核糖体，并与线粒体密切相关。在第三阶段，管状单元相互融合形成管状网状结构。在这个第三阶段，核糖体和线粒体几乎都不存在。由于此时这些细胞器几乎完全消失，附着的核糖体和线粒体可能在合成前体物质以及将其转化为管状网状结构的过程中发挥重要作用。
