Honig C R, Gayeski T E, Federspiel W, Clark A, Clark P
Adv Exp Med Biol. 1984;169:23-38. doi: 10.1007/978-1-4684-1188-1_2.
The capillary is the principal barrier at high Vo2. Mathematical modelling indicates that at high flow and Vo2 the time required for release of O2 is greater than red cell transit time in some capillaries. This convective shunting appears to be particularly important in the myocardium. The Mb acts to buffer Po2 below 5 Torr during muscle contraction. This greatly increases the transcapillary O2 gradient and promotes O2 delivery. During voluntary movements, Mb should act as a major O2 source in parallel with capillaries. The Kroghian model of the capillary as a "low-resistance" point source of O2 supplying a spatially uniform sink appears to be the reverse of the actual geometry of O2 supply to working red muscle.
在高摄氧量时，毛细血管是主要的屏障。数学模型表明，在高流量和高摄氧量时，某些毛细血管中氧气释放所需的时间大于红细胞通过时间。这种对流性分流在心肌中似乎尤为重要。肌红蛋白在肌肉收缩期间作用于缓冲低于5托的氧分压。这大大增加了跨毛细血管的氧梯度并促进了氧气输送。在自主运动期间，肌红蛋白应与毛细血管并行充当主要的氧气来源。将毛细血管视为向空间均匀的汇供应氧气的“低阻力”点源的克罗格模型，似乎与向工作中的红色肌肉供应氧气的实际几何形状相反。
