Elkayam U, McKay C R, Weber L, Eisenberg D, Rahimtoola S H
Am J Cardiol. 1984 Jun 1;53(11):1603-7. doi: 10.1016/0002-9149(84)90587-3.
The hemodynamic effects of isometric exercise and the response to hydralazine therapy were evaluated in 11 patients with chronic, severe aortic regurgitation (AR). Isometric exercise produced a significant increase in heart rate (from 78 +/- 11 to 93 +/- 19 beats/min [mean +/- standard deviation], p less than 0.05), mean blood pressure (from 83 +/- 8 to 104 +/- 20 mm Hg, p less than 0.05), mean right atrial pressure (from 3 +/- 2 to 7 +/- 5 mm Hg, p less than 0.05) and mean pulmonary artery wedge pressure (from 12 +/- 7 to 18 +/- 10 mm Hg, p less than 0.05). Small and insignificant changes were seen in cardiac index (from 3.4 +/- 0.8 to 3.9 +/- 1.0 liters/min/m2), systemic vascular resistance (from 1,097 +/- 257 to 1,171 +/- 284 dynes s cm-5), pulmonary vascular resistance (from 120 +/- 76 to 130 +/- 89 dynes s cm-5) and stroke volume index (from 44 +/- 10 to 43 +/- 12 ml/m2). After oral hydralazine administration (100 to 300 mg), hemodynamic values during isometric exercise were: Heart rate increased further, to 105 +/- 14 beats/min (p less than 0.05), mean blood pressure was 102 +/- 16 mm Hg (difference not significant [NS]) cardiac index increased markedly, to 5.2 +/- 1.4 liters/min/m2 (p less than 0.05), stroke volume index increased to 49 +/- 12 ml/m2 (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
对11例慢性重度主动脉瓣关闭不全（AR）患者评估了等长运动的血流动力学效应及对肼屈嗪治疗的反应。等长运动使心率显著增加（从78±11次/分钟增至93±19次/分钟[均值±标准差]，p<0.05），平均血压（从83±8 mmHg增至104±20 mmHg，p<0.05），平均右心房压（从3±2 mmHg增至7±5 mmHg，p<0.05）以及平均肺动脉楔压（从12±7 mmHg增至18±10 mmHg，p<0.05）。心脏指数（从3.4±0.8升/分钟/平方米增至3.9±1.0升/分钟/平方米）、体循环血管阻力（从1097±257达因·秒/厘米⁵增至1171±284达因·秒/厘米⁵）、肺血管阻力（从120±76达因·秒/厘米⁵增至130±89达因·秒/厘米⁵）和每搏量指数（从44±10毫升/平方米降至43±12毫升/平方米）有微小且不显著的变化。口服肼屈嗪（100至300毫克）后，等长运动期间的血流动力学值为：心率进一步增至105±14次/分钟（p<0.05），平均血压为102±16 mmHg（差异不显著[NS]），心脏指数显著增至5.2±1.4升/分钟/平方米（p<0.05），每搏量指数增至49±12毫升/平方米（p<0.05）。（摘要截于250字）
