Herlitz J, Ejdebäck J, Swedberg K, Waagstein F, Hjalmarson A
Am J Cardiol. 1984 Jun 25;53(13):22D-26D.
In 236 patients with anterior myocardial infarction (MI), infarct size was estimated by analyzing the R- and Q-wave amplitude in 24 precordial leads 4 days after randomization. In 254 patients with inferior MI, the final R- and Q-wave amplitude was evaluated in leads II, III and aVF. Electrocardiographic signs of a smaller MI were observed in anterior MI in the metoprolol group compared with the placebo group when treatment was started 12 hours or less after the onset of pain, but no difference was found when treatment was started later. There was no sign of an effect of metoprolol in inferior MI. An immediate reduction in ST-segment elevation was observed after metoprolol treatment regardless of infarct localization or delay between the onset of pain and treatment.
在236例前壁心肌梗死（MI）患者中，随机分组4天后，通过分析24个胸前导联的R波和Q波振幅来估计梗死面积。在254例下壁MI患者中，评估II、III和aVF导联的最终R波和Q波振幅。当在疼痛发作后12小时或更短时间开始治疗时，与安慰剂组相比，美托洛尔组在前壁MI中观察到较小MI的心电图迹象，但在疼痛发作后较晚开始治疗时未发现差异。美托洛尔在下壁MI中没有疗效迹象。无论梗死部位或疼痛发作与治疗之间的延迟如何，美托洛尔治疗后均观察到ST段抬高立即降低。
