Mills S E, Garland T A, Allen M S
Am J Surg Pathol. 1984 May;8(5):367-74. doi: 10.1097/00000478-198405000-00005.
The clinicopathologic features of five low-grade papillary adenocarcinomas of palatal salivary gland origin are presented and seven well-documented cases from the literature are reviewed. Patients in our series ranged in age from 30 to 77 years (median 48). Symptoms were nonspecific and related to a mass present for a long duration. Histologically, these were complex cystic, papillary, focally solid tumors that were partially encapsulated. Cytologically, they were composed of bland, predominantly cuboidal cells with eosinophilic or clear cytoplasm. Four tumors were initially considered to be benign mixed tumors, but long-term follow-up indicates that these are slowly growing, malignant neoplasms. Three patients developed solitary cervical lymph node metastases from 2 to 21 years after initial presentation. One tumor underwent an anaplastic transformation to solid adenocarcinoma, and this was from the only patient in our series who died with tumor. Low-grade papillary adenocarcinoma is a clinicopathologically distinctive salivary gland neoplasm, with histologic features unlike those of other papillary salivary gland tumors.
本文介绍了5例腭部涎腺来源的低级别乳头状腺癌的临床病理特征，并回顾了文献中7例记录详实的病例。我们系列研究中的患者年龄在30至77岁之间（中位数为48岁）。症状不具特异性，与长期存在的肿物有关。组织学上，这些肿瘤为复杂的囊性、乳头状、局灶实性肿瘤，部分有包膜。细胞学上，它们由温和的、主要为立方状的细胞组成，细胞质呈嗜酸性或透明状。4例肿瘤最初被认为是良性混合瘤，但长期随访表明这些是生长缓慢的恶性肿瘤。3例患者在初次就诊后2至21年出现孤立性颈部淋巴结转移。1例肿瘤发生间变转化为实性腺癌，该患者是我们系列研究中唯一因肿瘤死亡的患者。低级别乳头状腺癌是一种临床病理特征独特的涎腺肿瘤，其组织学特征与其他乳头状涎腺肿瘤不同。
