von Knorring L
Neuropsychobiology. 1978;4(5):314-20. doi: 10.1159/000117645.
19 patients with bipolar affective disorders were investigated with visual averaged evoked responses (V.AER) to different stimulus intensities. 7 patients were investigated only in the depressive phase, 8 only in the manic phase, 2 in both the depressive and the manic phase, 1 in the manic phase and after recovery, and 1 patient was followed in both the depressive and the manic phase and when recovered. Both the comparisons between the independent groups and the results from the individual patients followed in different phases of the disorder indicate that patients in the depressive phase have a tendency to decrease in maximum amplitude when stimulus intensity is increased (reducing). Patients in the manic phase, on the other hand, show increasing maximum amplitude with increasing stimulus intensity (augmenting). The biochemical basis for this switch in augmenting/reducing tendency seem to be changes in the activity in the monoaminergic systems.
对19例双相情感障碍患者进行了研究，观察他们对不同刺激强度的视觉平均诱发电位（V.AER）。7例患者仅在抑郁期接受研究，8例仅在躁狂期接受研究，2例在抑郁期和躁狂期均接受研究，1例在躁狂期及康复后接受研究，1例患者在抑郁期、躁狂期及康复后均接受跟踪研究。独立组之间的比较以及对处于疾病不同阶段的个体患者的研究结果均表明，抑郁期患者在刺激强度增加时最大波幅有降低的趋势（衰减）。另一方面，躁狂期患者的最大波幅随刺激强度增加而升高（增强）。这种增强/衰减趋势转变的生化基础似乎是单胺能系统活性的变化。
