McGrath C J, Lee J C, Rempel W E
Am J Vet Res. 1984 May;45(5):935-7.
Pietrain pigs susceptible to malignant hyperthermia (MH; porcine stress syndrome) were treated with the slow-channel calcium blocker verapamil and then subjected to halothane testing. There was no significant delay in the onset of MH among pigs (3 groups) given different doses of verapamil (1, 5, and 10 mg/kg) and saline control Pietrain pigs. The mortality due to MH (83.3%) was significantly higher among the pigs given the largest dose (10 mg/kg) than in the other groups. Verapamil was not effective in preventing or delaying a MH reaction. This antiarrhythmic drug should be used cautiously during a MH reaction in susceptible individuals.
对易患恶性高热（MH；猪应激综合征）的皮特兰猪用慢通道钙阻滞剂维拉帕米进行治疗，然后进行氟烷测试。给予不同剂量维拉帕米（1、5和10毫克/千克）的猪（3组）和生理盐水对照的皮特兰猪之间，MH发作时间没有显著延迟。给予最大剂量（10毫克/千克）的猪中因MH导致的死亡率（83.3%）显著高于其他组。维拉帕米在预防或延迟MH反应方面无效。在易患个体发生MH反应期间，应谨慎使用这种抗心律失常药物。
