Ito Y, Jimbow K, Miura S, Maeda K
Gan To Kagaku Ryoho. 1984 Jun;11(6):1263-8.
Interferon (IFN) beta was applied locally to skin lesions of malignant melanoma (MM: 3 cases in stage IV and 1 case in stage II) and malignant lymphoma (ML: 3 cases of mycosis fungoides in stages II-III and 1 case of primary cutaneous lymphoma in stage III). It was found that IFN beta was remarkably effective for ML (3 in CR and 1 in PR), but far less effective for MM (3 in PD and 1 in NC). Biopsy specimens of clinically regressed areas revealed histopathology entirely different from each other, skin lesion of MM being infiltrated by numerous inflammatory cells such as lymphocytes and macrophages, whereas that of ML infiltrated Least. Local application of IFN beta appears to provide a new modality for treatment of cutaneous ML, which has the primary lesions on skin and has been hardly controlled by systemic chemoimmunotherapy.
将干扰素（IFN）β局部应用于恶性黑色素瘤（MM：IV期3例，II期1例）和恶性淋巴瘤（ML：II - III期蕈样肉芽肿3例，III期原发性皮肤淋巴瘤1例）的皮肤病变处。结果发现，IFNβ对ML有显著疗效（3例完全缓解，1例部分缓解），但对MM的疗效则差得多（3例疾病进展，1例病情稳定）。临床消退区域的活检标本显示组织病理学完全不同，MM的皮肤病变有大量炎性细胞如淋巴细胞和巨噬细胞浸润，而ML的浸润最少。局部应用IFNβ似乎为皮肤ML的治疗提供了一种新方法，皮肤ML以皮肤原发性病变为主，难以通过全身化学免疫疗法控制。
