Huerta F, Pourrias B
Arch Int Pharmacodyn Ther. 1984 Apr;268(2):216-24.
The benzofuran derivative carocainide is a new class I antiarrhythmic drug which has been shown to prevent and stop experimental ventricular arrhythmias. The effects of this drug on different types of cardiac automaticity were investigated by experimental models using "in situ" dogs' hearts. Complete A-V block was produced by local formaldehyde injection into the A-V junction. Carocainide at doses of 2.5, 5 and 7.5 mg/kg body weight i.v. produced the following effects: a significant and dose-related slowing of the idioventricular rate; a non-significant change of the sinus rate at 2.5 and 5 mg/kg b.w.; and a significant decrease of the total number of triggered ventricular beats induced by ventricular pacing during slow norepinephrine infusion. Our results suggest that carocainide could be a safe and effective drug for the treatment of ventricular arrhythmias.
苯并呋喃衍生物卡罗卡尼是一种新型I类抗心律失常药物，已被证明可预防和终止实验性室性心律失常。采用“原位”犬心实验模型研究了该药物对不同类型心脏自律性的影响。通过向房室交界区局部注射甲醛产生完全性房室传导阻滞。静脉注射体重2.5、5和7.5 mg/kg的卡罗卡尼产生以下效应：室性自主心率显著且剂量相关地减慢；体重2.5和5 mg/kg时窦性心率无显著变化；在缓慢输注去甲肾上腺素期间，心室起搏诱发的触发室性搏动总数显著减少。我们的结果表明，卡罗卡尼可能是一种治疗室性心律失常的安全有效药物。
