Lerner B C, Varma S D, Richards R D
Arch Ophthalmol. 1984 Jun;102(6):917-20. doi: 10.1001/archopht.1984.01040030737033.
Circulating glycosylated hemoglobin (Hb A1) and/or fasting blood glucose (FBG) levels, measures of the extent to which diabetes is clinically controlled, were correlated with the contents of fructose, sorbitol, glucose, and inositol in 27 cataracts removed by intracapsular extraction. In the series of patients studied, Hb A1 levels ranged from 6.0% to 15.5% of the total hemoglobin value. The levels of fructose and sorbitol (micromoles per gram of lens) in their cataracts ranged from 0 to 8.4 and 0 to 10.2 mumole/g, respectively, with correlation coefficients greater than .8. Similar correlations were noted with FBG. The Hb A1 correlated with lens glucose (r = .58) and not with inositol. However, FBG had no correlation with either lens glucose or inositol. The observed correlation of the polyol pathway metabolites with both Hb A1 and FBG suggests that the lens can synthesize substantial quantities of sorbitol and fructose in response to the excess glucose available to lenses of human diabetics. A synergistic role of the polyol pathway in the cause of senile cataracts is thus possible.
循环糖化血红蛋白（Hb A1）和/或空腹血糖（FBG）水平是糖尿病临床控制程度的指标，它们与通过囊内摘除术取出的27例白内障中果糖、山梨醇、葡萄糖和肌醇的含量相关。在所研究的患者系列中，Hb A1水平占总血红蛋白值的6.0%至15.5%。他们白内障中的果糖和山梨醇水平（每克晶状体微摩尔数）分别为0至8.4和0至10.2微摩尔/克，相关系数大于0.8。FBG也有类似的相关性。Hb A1与晶状体葡萄糖相关（r = 0.58），与肌醇无关。然而，FBG与晶状体葡萄糖或肌醇均无相关性。观察到多元醇途径代谢物与Hb A1和FBG均相关，这表明晶状体能够响应人类糖尿病患者晶状体中过量的葡萄糖而合成大量的山梨醇和果糖。因此，多元醇途径在老年性白内障病因中可能起协同作用。
