Gorce P, Wade A E
Biochem Biophys Res Commun. 1984 May 31;121(1):237-42. doi: 10.1016/0006-291x(84)90712-5.
Administration of a single dose of the potent interferon inducer poly rI:rC to Swiss Webster mice depressed hepatic cytochrome P-450 to 75% of control, ethylmorphine N-demethylase to 56% of control and DMN N- demethylases I and II to about 80% of control. Although each enzyme responded in a unique manner, maximum depression occurred at 24 hours after poly rI:rC administration and the concurrent administration of inhibitors of protein synthesis (actinomycin D or cycloheximide) prevented this depression. These data suggest that poly rI:rC effects on the mixed function oxidases are not species specific although depression follows a time course shorter than that reported in the rat (maximum depression at 40 hours after poly rI:rC administration) and that depression occurs through the stimulation of a protein responsible for degrading cytochrome P-450.
聚胞苷酸（poly rI:rC）后，肝脏细胞色素P-450降至对照组的75%，乙基吗啡N-脱甲基酶降至对照组的56%，二甲基亚硝胺N-脱甲基酶I和II降至对照组的约80%。尽管每种酶的反应方式独特，但聚肌苷酸:聚胞苷酸给药后24小时出现最大程度的抑制，同时给予蛋白质合成抑制剂（放线菌素D或环己酰亚胺）可防止这种抑制。这些数据表明，聚肌苷酸:聚胞苷酸对混合功能氧化酶的作用并非物种特异性，尽管其抑制作用的时程比在大鼠中报道的要短（聚肌苷酸:聚胞苷酸给药后40小时出现最大抑制），并且这种抑制是通过刺激一种负责降解细胞色素P-450的蛋白质而发生的。
