华法林与普萘洛尔之间的相互作用。
Interaction between warfarin and propranolol.
作者信息
Scott A K, Park B K, Breckenridge A M
出版信息
Br J Clin Pharmacol. 1984 May;17(5):559-64. doi: 10.1111/j.1365-2125.1984.tb02390.x.
The interaction between propranolol and warfarin was investigated in six healthy volunteers using a low dose warfarin protocol and in New Zealand white rabbits. Warfarin concentration (Cmin) in the volunteers increased by 14.7% on addition of propranolol (P less than 0.02). There was no significant change in prothrombin time. In the rabbit study, elimination half-life was shorter in the propranolol treated animals (8.20 +/- 0.44 h) than in controls (10.89 +/- 0.62 h). This was due to a fall in its volume of distribution from 1.13 +/- 0.10 1 kg-1 in controls to 0.81 +/- 0.08 1 kg-1 in the propranolol treated group. Clearance was not significantly altered. The small change in warfarin concentration could be of clinical importance in some patients because warfarin has a low therapeutic index. This requires further investigation.
在6名健康志愿者中采用低剂量华法林方案，并在新西兰白兔身上研究了普萘洛尔与华法林之间的相互作用。加入普萘洛尔后，志愿者体内的华法林浓度。（Cmin）升高了14. 7%（P<0. 02）。凝血酶原时间无显著变化。在兔子实验中，普萘洛尔治疗组动物的消除半衰期（8. 20±0. 44小时）比对照组（10. 89±0. 62小时）短。这是由于其分布容积从对照组的1. 13±0. 10升/千克降至普萘洛尔治疗组的0. 81±0. 08升/千克。清除率无显著改变。华法林浓度的微小变化在某些患者中可能具有临床意义，因为华法林的治疗指数较低。这需要进一步研究。
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