硝酸异山梨酯、2-单硝酸异山梨酯和5-单硝酸异山梨酯的唾液浓度。
Saliva concentrations of isosorbide dinitrate, isosorbide 2-mononitrate and isosorbide 5-mononitrate.
作者信息
Taylor I W, Major R M, Chasseaud L F, Taylor T
出版信息
Br J Clin Pharmacol. 1984 May;17(5):585-7. doi: 10.1111/j.1365-2125.1984.tb02394.x.
Correlations between saliva and plasma concentrations of isosorbide dinitrate (ISDN), and its active metabolites, isosorbide 2-mononitrate (2-ISMN) and isosorbide 5-mononitrate (5-ISMN) were examined. In the case of 5-ISMN (r = 0.98, P less than 0.01), saliva concentrations are probably reliable indices of the plasma concentrations of this drug and their measurement should provide a useful non-invasive procedure to assess compliance during the clinical use of products containing either ISDN or 5-ISMN: it may also be helpful in assessing the clinical pharmacokinetics of 5-ISMN. Less satisfactory correlations were obtained for ISDN (r = 0.84) and 2-ISMN (r = 0.83).
研究了唾液与血浆中硝酸异山梨酯（ISDN）及其活性代谢物5-单硝酸异山梨酯（5-ISMN）和2-单硝酸异山梨酯（2-ISMN）浓度之间的相关性。对于5-ISMN（r = 0.98，P小于0.01），唾液浓度可能是该药物血浆浓度的可靠指标，其测量可为评估含ISDN或5-ISMN产品临床使用期间的依从性提供一种有用的非侵入性方法：这也可能有助于评估5-ISMN的临床药代动力学。对于ISDN（r = 0.84）和2-ISMN（r = 0.83），相关性不太令人满意。
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