Asakura T, Shibutani Y, Reilly M P, DeMeio R H
Blood. 1984 Jul;64(1):305-7.
Potassium tellurite (K2TeO3) was found to be a potent antisickling agent that inhibited red cell sickling at concentrations less than 10 mumol/L. The inhibitory effect depended on the incubation time, with the effect increasing with longer incubation periods. Because tellurite causes swelling of red cells, and because the antisickling effect of tellurite correlated with the degree of red cell swelling, the antisickling effect of tellurite is assumed to be due to the decreased mean cell hemoglobin concentration. Swelling of red cells by tellurite was accelerated by the addition of reduced glutathione. Tellurite appears to be a new type of antisickling agent that interacts with the red cell membrane.
亚碲酸钾（K2TeO3）被发现是一种有效的抗镰变剂，在浓度低于10 μmol/L时就能抑制红细胞镰变。其抑制作用取决于孵育时间，孵育时间越长，效果越明显。由于亚碲酸盐会导致红细胞肿胀，且亚碲酸盐的抗镰变作用与红细胞肿胀程度相关，因此推测亚碲酸盐的抗镰变作用是由于平均细胞血红蛋白浓度降低所致。添加还原型谷胱甘肽可加速亚碲酸盐引起的红细胞肿胀。亚碲酸盐似乎是一种新型的与红细胞膜相互作用的抗镰变剂。
