Venning M G, de la Lande I S
Blood Vessels. 1984;21(4):149-55. doi: 10.1159/000158507.
The action of adrenaline on the rat tail artery was similar to that of noradrenaline in that (i) adrenaline was more potent by the intraluminal than the extraluminal route of application, and (ii) cocaine eliminated the difference in potency by selectively enhancing the response to extraluminal adrenaline. In the absence of cocaine, extraluminal adrenaline was more potent than extraluminal noradrenaline; in the presence of cocaine, the two amines were equipotent, irrespective of the route of application. The intraluminal and extraluminal potencies of methoxamine did not differ, either in the absence or presence of cocaine. It is concluded that neuronal uptake is responsible for differences between the potencies of noradrenaline and adrenaline and for the effect of the route of applications on these potencies. Potentiation of responses to both noradrenaline and adrenaline by 27 microM deoxycorticosterone acetate was minor compared with that by cocaine. The results provide further evidence that in the rat tail artery the extraneuronal uptake system is poorly developed compared with the neuronal uptake system.
肾上腺素对大鼠尾动脉的作用与去甲肾上腺素相似，即：（i）通过腔内给药途径，肾上腺素比去甲肾上腺素更有效；（ii）可卡因通过选择性增强对腔外肾上腺素的反应消除了效力差异。在没有可卡因的情况下，腔外肾上腺素比腔外去甲肾上腺素更有效；在有可卡因的情况下，两种胺类药物等效，无论给药途径如何。甲氧明的腔内和腔外效力在有无可卡因的情况下均无差异。得出的结论是，神经元摄取是去甲肾上腺素和肾上腺素效力差异以及给药途径对这些效力影响的原因。与可卡因相比，27微摩尔醋酸脱氧皮质酮对去甲肾上腺素和肾上腺素反应的增强作用较小。结果进一步证明，在大鼠尾动脉中，与神经元摄取系统相比，非神经元摄取系统发育不良。
