Howard R C, Fenton G W, Fenwick P B
Br J Psychiatry. 1984 May;144:463-74. doi: 10.1192/bjp.144.5.463.
Using a classical click/flash paradigm the contingent negative variation (CNV) was recorded from 60 consecutive male admissions to Broadmoor Hospital. Clinical and psychometric Minnesota Multiphasic Personality Inventory (MMPI) assessments were made independently of the electroencephalography (EEG) data. A trend for higher amplitude CNV's to be recorded from patients with a clinical diagnosis of antisocial (psychopathic) personality was observed. Patients with a Mental Health Act diagnosis of psychopathic disorder had significantly higher voltage CNV's than those in the mental illness category. These CNV differences were only found in the primary (non-anxious, sociable) psychopaths. Secondary (neurotic, unsociable) psychopaths did not differ from staff controls. A positive association between CNV voltage and the personality factor of sociability(sociable-shy dimension) was observed. A weak, negative correlation between CNV amplitude and impulsivity (impulsive-controlled dimension) was also apparent. All subjects showed an habituation effect across trials. No difference in response variability between successive series of trials was apparent in any of the patient groups.
采用经典的点击/闪光范式，对连续60名入住布罗德莫尔医院的男性患者记录关联性负变（CNV）。明尼苏达多相人格调查表（MMPI）的临床和心理测量评估独立于脑电图（EEG）数据进行。观察到临床诊断为反社会（精神病态）人格的患者记录到的CNV振幅有升高趋势。根据《精神健康法》诊断为精神病态障碍的患者的CNV电压明显高于精神疾病类别的患者。这些CNV差异仅在原发性（非焦虑、善社交）精神病患者中发现。继发性（神经质、不善社交）精神病患者与工作人员对照组没有差异。观察到CNV电压与社交性人格因素（社交-害羞维度）之间存在正相关。CNV振幅与冲动性（冲动-自控维度）之间也存在微弱的负相关。所有受试者在各次试验中均表现出习惯化效应。在任何患者组中，连续系列试验之间的反应变异性均无差异。
