Montelius A, Burlin T E
Br J Radiol. 1984 Jul;57(679):609-16. doi: 10.1259/0007-1285-57-679-609.
The previous work on the dosimetry of alpha-emitting radionuclides incorporated in bone is briefly reviewed. The application of cavity ionisation theory to problems of bone dosimetry is propounded and recent developments of the cavity theory for alpha particle fields are applied to bone dosimetry problems. The mean marrow dose over a large range of bone cavity size calculated by a simple theory using a mean chord length to characterise a cavity is compared with results of a more elaborate theory employing the chord length distribution for a sphere. The difference is not great. The influence of the shape of the cavity is explored by considering cylindrical cavities of different elongation. Data are presented for both volume-seeking and surface-seeking radioactive nuclides. The endosteal dose to a 10 mu layer is calculated as a function of cavity size for both volume-seeking and surface-seeking radioactive nuclides. The endosteal dose is also calculated for a surface seeker as a function of endosteal layer thickness. Finally, the results of these calculations are shown to be generally in good agreement with those of the calculations of earlier workers. It is concluded that a simple and reliable method of calculating the mean marrow dose and endosteal dose for both volume- and surface-seeking alpha emitters has been established.
本文简要回顾了以往关于掺入骨骼中的发射α粒子放射性核素剂量学的研究工作。提出了将空腔电离理论应用于骨骼剂量学问题，并将α粒子场空腔理论的最新进展应用于骨骼剂量学问题。通过使用平均弦长来表征空腔的简单理论计算出的大范围骨腔大小上的平均骨髓剂量，与采用球体弦长分布的更精细理论的结果进行了比较。差异不大。通过考虑不同伸长率的圆柱形空腔来探讨空腔形状的影响。给出了体积寻靶和表面寻靶放射性核素的数据。计算了体积寻靶和表面寻靶放射性核素的10微米层骨内膜剂量随腔大小的变化。还计算了表面寻靶放射性核素的骨内膜剂量随骨内膜层厚度的变化。最后，这些计算结果与早期工作者的计算结果总体上吻合良好。得出结论，已建立了一种简单可靠的方法来计算体积寻靶和表面寻靶α发射体的平均骨髓剂量和骨内膜剂量。
