Dorovini-Zis K, Bowman P D, Betz A L, Goldstein G W
Brain Res. 1984 Jun 8;302(2):383-6. doi: 10.1016/0006-8993(84)90254-3.
Tight junctions between bovine brain capillary endothelial cells in primary cell culture are impermeable to horseradish peroxidase (HRP) after 5 min of incubation. However, following 1-5 min of exposure to 1.6 M arabinose, HRP penetrates the extracellular space between successive tight junctions. Endothelial cells in control cultures contain a small number of cytoplasmic pits and vesicles containing HRP which do not increase in number after hyperosmotic treatment.
