Postnatal development of cat superior colliculus. I. Presumptive neurons, immature neurons and degenerating cells in the intermediate and deep layers.

Presumptive neurons, immature neurons and degenerating structures were found in the intermediate and deep layers of the superior colliculus of normal cats over the age range 7-45 days postnatal. Electron microscopical analysis revealed these structures to be unexpectedly frequent in the early postnatal period. There were 34 immature neurons per 1000 neurons at 7-8 days and 78 per 1000 neurons at 14 days postnatal. Few were found in older cats. Two types of degenerative changes in the neurons were observed: nuclear and cytoplasmic. The number of degenerating structures to be unexpectedly frequent in the early postnatal period. There were 34 immature neurons per 1000 neurons at 7-8 days and 78 per 1000 neurons at 14 days postnatal. Few were found in older cats. Two types of degenerative changes in the neurons were observed: nuclear and cytoplasmic. The number of degenerating neurons was higher at 14 days (28 per 1000 neurons) than at 7-8 days (21 per 1000 neurons), but only a few were found at 30 and 45 days. Degenerative changes were noted in synaptic terminals at all ages studied. The greatest number of degenerating synaptic profiles were observed at 14 and 30 days. They were infrequent in younger or older animals. The number of presumptive neurons does not change significantly over 7-14 days. It is speculated that they persist as a reverse pool of neurons. The increasing number of immature neurons in the period between 7 and 14 days indicates that formation of new cells in the intermediate and deep layers of the superior colliculus continues into the early postnatal period. The degeneration of some neurons and synapses over the same developmental period suggest that the final adjustment of the neuronal composition of the superior colliculus occurs postnatally.