一些血小板活化因子（PAF）类似物的降压作用，其效力高于天然PAF。
Hypotensive actions of some analogues of platelet-activating factor (PAF) with higher potencies than natural PAF.
作者信息
Kasuya Y, Masuda Y, Shigenobu K
出版信息
Can J Physiol Pharmacol. 1984 Apr;62(4):457-9. doi: 10.1139/y84-073.
DOI:10.1139/y84-073
PMID:6733593
Abstract
Substituents on the nitrogen atom of the phosphorylcholine moiety of natural C16 platelet-activating factor (PAF) were modified or replaced by more bulky groups, and their hypotensive activities were examined with rats. As a result, it was found that N-methylpiperidine and N-methylpyrrolidine analogues were 3-10 times more potent than natural C16-PAF.
摘要
天然C16血小板活化因子（PAF）磷酰胆碱部分氮原子上的取代基被更大的基团修饰或取代，并在大鼠身上检测了它们的降压活性。结果发现，N-甲基哌啶和N-甲基吡咯烷类似物的活性比天然C16-PAF高3至10倍。
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