Witmer D R, Ritschel W A
Drug Intell Clin Pharm. 1984 Jun;18(6):483-6. doi: 10.1177/106002808401800607.
A case of phenytoin-isoniazid drug interaction is reported. Pharmacokinetic evaluation was performed on the basis of two different phenytoin serum concentrations obtained on two different dosage regimens. Whereas Vmax was found to be in the normal range, the patient's Km was increased five-fold. The literature regarding this interaction is reviewed. This case illustrates the usefulness of pharmacokinetic methods in the management of phenytoin-isoniazid interaction.
报告了一例苯妥英钠与异烟肼药物相互作用的病例。根据在两种不同给药方案下获得的两种不同苯妥英血清浓度进行了药代动力学评估。虽然发现最大反应速度（Vmax）在正常范围内，但患者的米氏常数（Km）增加了五倍。对有关这种相互作用的文献进行了综述。该病例说明了药代动力学方法在处理苯妥英钠与异烟肼相互作用中的实用性。
