Woodward D F, Weichman B M, Wasserman M A
Eur J Pharmacol. 1984 Apr 20;100(2):219-22. doi: 10.1016/0014-2999(84)90226-7.
The effects of systemically administered salbutamol on LTD4-induced changes in pulmonary mechanics and tracheal microvascular permeability in the anesthetized guinea pig were compared. Salbutamol (50 micrograms/kg i.v.) virtually abolished the decreases in Cdyn and Gaw produced by i.v. LTD4, but did not alter the LTD4-induced increase in tracheal microvascular permeability. Thus, it appears that although the spasmolytic properties of salbutamol may profoundly inhibit LTD4-mediated bronchoconstriction, salbutamol might only be of limited value in reducing the airway inflammatory effects of LTD4.
比较了全身给予沙丁胺醇对麻醉豚鼠中白三烯D4（LTD4）诱导的肺力学变化和气管微血管通透性变化的影响。静脉注射沙丁胺醇（50微克/千克）几乎消除了静脉注射LTD4所引起的动态顺应性（Cdyn）和气道阻力（Gaw）的降低，但并未改变LTD4诱导的气管微血管通透性增加。因此，虽然沙丁胺醇的解痉特性可能会显著抑制LTD4介导的支气管收缩，但在减轻LTD4的气道炎症作用方面，沙丁胺醇的价值可能有限。
