反复电休克后大鼠出现的可逆性运动麻痹

Reversible motor paralysis in rats after repeated electroconvulsive shock.

作者信息

Isaac L, Advokat C

出版信息

Exp Neurol. 1984 Jul;85(1):87-96. doi: 10.1016/0014-4886(84)90163-8.

Abstract

Repeated electroconvulsive shocks (ECS) delivered at brief (10 to 15 min) intervals through earclip electrodes, induced a reversible motor paralysis in 35% of treated rats. Paralysis was characterized by loss of locomotor activity without apparent loss of sensory functions. It occurred after 10 to 13 shocks regardless of whether stimulation was of subthreshold (40 to 60 mA) or suprathreshold (65 mA) intensity. This phenomenon may provide a useful animal model for the investigation of reversible injury to the spinal cord.

摘要

通过耳夹电极以短暂（10至15分钟）的间隔重复进行电惊厥休克（ECS），在35%的受试大鼠中诱发了可逆性运动麻痹。麻痹的特征是运动活动丧失，而感觉功能无明显丧失。无论刺激是阈下强度（40至60毫安）还是阈上强度（65毫安），在10至13次电击后都会出现这种情况。这种现象可能为研究脊髓可逆性损伤提供一个有用的动物模型。