Kuz'min A I, Kukes V G, Chekhmakina O V
Farmakol Toksikol. 1984 May-Jun;47(3):108-14.
Nine patients with normal live and renal functions were examined for the pharmacokinetics of zixorine after a single oral administration in a dose of 300 mg. In 7 of these patients given multiple doses of zixorine, its pharmacokinetics was reinvestigated. Six of the 7 patients manifested deceleration of drug biotransformation instead of expected self-induction of biotransformation. The reasons for such a phenomenon are discussed. Four patients were examined for the time course of zixorine biotransformation.
