Legeza V I, Shagoian M G, Kamynina M F
Farmakol Toksikol. 1984 May-Jun;47(3):41-3.
It has been established in dog experiments that phentolamine prevents the emetic action of adrenaline whereas diphenhydramine the emetic effect of histamine. Both the drugs in the doses studied do not produce any effect on vomiting induced by L-DOPA. The dopamine blockers, etaperazine, haloperidol and metoclopramide given in the doses suppressing the emetic action of L-DOPA do not prevent the adrenaline- and histamine-induced vomiting. It is assumed that the emetic action of adrenaline is effected in dogs via alpha-adrenoreceptors, whereas the histamine-induced vomiting via H1-histamine receptors of the trigger zone of the vomiting center.
在犬实验中已证实，酚妥拉明可预防肾上腺素的催吐作用，而苯海拉明可预防组胺的催吐作用。在所研究的剂量下，这两种药物对左旋多巴引起的呕吐均无任何作用。以抑制左旋多巴催吐作用的剂量给予多巴胺阻滞剂乙哌立嗪、氟哌啶醇和甲氧氯普胺，不能预防肾上腺素和组胺引起的呕吐。据推测，肾上腺素在犬体内的催吐作用是通过α-肾上腺素能受体实现的，而组胺引起的呕吐是通过呕吐中枢触发区的H1组胺受体实现的。
