Serov N V, Treskov V G, Berliand A S, Knizhnik A Z, Lapin K V
Farmakol Toksikol. 1984 May-Jun;47(3):94-7.
Twenty-two patients admitted to the narcological clinic of an industrial enterprise were examined for the clinical effect and pharmacokinetic parameters after intake of a single dose of a Soviet psychotropic drug mebicar. The clinical status was assessed by means of psychometric mapping and concurrent recording of the EEG. The correlation of the pharmacodynamic and pharmacokinetic data can be used for the choice of minimal effective concentrations applied in further calculations of individual dosage regimens.
对一家工业企业麻醉科收治的22名患者进行了研究，在他们单次服用苏联精神药物美比卡后，检测其临床效果和药代动力学参数。通过心理测量图谱和同步记录脑电图来评估临床状态。药效学和药代动力学数据的相关性可用于选择最小有效浓度，以便在进一步计算个体给药方案时应用。
