Cooke H J, Pitman K, Starr G, Wood J D
Gastroenterology. 1984 Aug;87(2):357-61.
Gastric emptying and small intestinal transit were investigated in the piebald mouse model for Hirschsprung's disease. These mice exhibited aganglionosis of the terminal segment of the large intestine. This condition was accompanied by fecal stasis and megacolon. Gastric emptying of saline or milk meals was slower in the mice with aganglionic or induced megacolon than in the normal mice, but the rate of emptying was faster than after administration of morphine (10 mg/kg). In the small intestine, the distribution of the radiolabeled marker and the advancing edge of the marker profile were abnormal in the mice with megacolon. There were small differences between the megacolonic and normal mice in the distance traversed by the advancing edge of the intraluminal profile of the marker. These results are evidence for disturbances of gastric and small intestinal motor function that occur in mice secondary to development of megacolon.
在斑驳小鼠的先天性巨结肠模型中研究了胃排空和小肠转运情况。这些小鼠表现出大肠末端节段的神经节缺失。这种情况伴有粪便淤滞和巨结肠。与正常小鼠相比，患有神经节缺失或诱导性巨结肠的小鼠对盐水或奶餐的胃排空较慢，但排空速率比给予吗啡（10毫克/千克）后要快。在小肠中，患有巨结肠的小鼠体内放射性标记物的分布以及标记物轮廓的推进边缘均异常。巨结肠小鼠与正常小鼠在标记物管腔内轮廓推进边缘所经过的距离上存在微小差异。这些结果证明，巨结肠形成继发于小鼠后会出现胃和小肠运动功能紊乱。
