Bradshaw S D, Lemire M, Vernet R, Grenot C J
Gen Comp Endocrinol. 1984 May;54(2):314-23. doi: 10.1016/0016-6480(84)90186-2.
The secretory response of the nasal salt gland of the north African agamid lizard Uromastix acanthinurus to injections of 1 M KCl and NaCl is correlated with changes in circulating levels of the corticosteroids aldosterone and corticosterone. KCl loading led to a progressive rise in plasma aldosterone levels, and NaCl loading was associated with a fall. Neither treatment significantly altered plasma corticosterone concentrations which remained at levels characteristic of unstressed animals. Rates of potassium excretion were positively correlated with circulating levels of aldosterone whereas sodium excretion showed a negative correlation. As in previous studies, injections of exogenous aldosterone or dexamethasone into KCl-loaded animals failed to further stimulate potassium excretion, but did depress sodium excretion by the gland. Spironolactone, an aldosterone antagonist in mammals, was without effect on the rate of potassium excretion in KCl-injected animals. These data suggest that aldosterone functions as a mineralocorticoid on the nasal gland of U. acanthinurus (i.e., natriferic and kaliuretic) but direct evidence of this will require the use of adrenalectomized animals.
北非鬣蜥（Uromastix acanthinurus）鼻盐腺对注射1 M氯化钾和氯化钠的分泌反应与皮质类固醇醛固酮和皮质酮循环水平的变化相关。注射氯化钾导致血浆醛固酮水平逐渐升高，而注射氯化钠则导致其水平下降。两种处理均未显著改变血浆皮质酮浓度，其浓度仍处于未受应激动物的特征水平。钾排泄率与醛固酮循环水平呈正相关，而钠排泄则呈负相关。与之前的研究一样，向注射氯化钾的动物体内注射外源性醛固酮或地塞米松未能进一步刺激钾排泄，但确实会抑制该腺体的钠排泄。螺内酯是哺乳动物中的醛固酮拮抗剂，对注射氯化钾的动物的钾排泄率没有影响。这些数据表明，醛固酮在北非鬣蜥的鼻腺中起盐皮质激素的作用（即排钠和利尿钾），但要得到这方面的直接证据需要使用肾上腺切除的动物。
