Horbelt D V, Freedman R S, Roberts D K, Walker N J, Edwards C L, Jones L A
Gynecol Oncol. 1984 Jun;18(2):150-6. doi: 10.1016/0090-8258(84)90022-2.
Eighteen (18) previously untreated patients with grade I (9) and II (9) endometrial adenocarcinoma provided endometrial samples for biochemical analysis of estrogen and progesterone receptors. The same samples were evaluated by histology and ultrastructure. Progesterone receptor negative samples (PR less than 1000 fmole/g tissue) showed more ultrastructural characteristics of malignancy and a wider range of changes than the progesterone positive specimens (PR greater than 1000 fmole/g tissue). These findings appeared to be independent of estrogen receptor status. No significant ultrastructural changes were seen when grades I and II were compared.
18例先前未经治疗的I级（9例）和II级（9例）子宫内膜腺癌患者提供了子宫内膜样本，用于雌激素和孕激素受体的生化分析。对相同样本进行了组织学和超微结构评估。与孕激素受体阳性标本（PR大于1000飞摩尔/克组织）相比，孕激素受体阴性样本（PR小于1000飞摩尔/克组织）显示出更多的恶性超微结构特征和更广泛的变化范围。这些发现似乎与雌激素受体状态无关。比较I级和II级时，未观察到明显的超微结构变化。
