Timmer P R, Aalders J G, Bouma J
Gynecol Oncol. 1984 Jun;18(2):206-12. doi: 10.1016/0090-8258(84)90027-1.
During the years 1970-1978 one hundred nineteen patients with Stage IB and fifty-eight patients with Stage IIA carcinoma of the cervix were treated by combined preoperative radium and Wertheim hysterectomy with lymphadenectomy at the State University Hospital in Groningen. The overall 5-year survival was 87% for Stage IB and 70% for Stage IIA. The incidence of pelvic lymph node metastases was 14.8 and 35.4% in Stage IB and IIA, respectively. The presence of lymph node metastases was significantly related to the presence of residual tumour in the cervix after preoperative radium treatment (P less than 0.01) and was the most significant prognostic factor. The 5-year survival was 37% for those patients with node involvement as compared to 94% for those without lymphatic extension. Complications particularly concerned the urinary tract. The incidence of these complications was greatly reduced as experience grew.
1970年至1978年期间，格罗宁根州立大学医院对119例IB期宫颈癌患者和58例IIA期宫颈癌患者采用术前镭疗联合韦特海姆子宫切除术及淋巴结清扫术进行治疗。IB期患者的总体5年生存率为87%，IIA期患者为70%。IB期和IIA期盆腔淋巴结转移发生率分别为14.8%和35.4%。淋巴结转移的存在与术前镭疗后宫颈残留肿瘤的存在显著相关（P<0.01），是最重要的预后因素。有淋巴结受累的患者5年生存率为37%，而无淋巴转移的患者为94%。并发症主要涉及泌尿系统。随着经验的积累，这些并发症的发生率大幅降低。
