Voigt J, Lennert K, Hedderich J
Fortschr Med. 1984 May 24;102(20):562-4.
Despite wide use of physical methods the number of fatal postoperative pulmonary embolisms in surgical patients increased in Kiel until 1976. Because of these results, additional general prophylaxis with 2-3 X 5000 i U of heparin-dihydroergotamine was introduced in 1978. The rate of fatal pulmonary embolism in general surgery proven by autopsy decreased to 0,3% between 1979 and 1983. It should be noted that six of the nine patients who died from pulmonary embolism had also suffered from an infaust disease. This is an excellent result since our study also includes high risk patients after emergency surgery, cases which Kakkar and Gruber did not include in their studies. Due to the extensive analysis of medical records and the pertinent post-mortem reports, the high effectivity of drug induced prophylaxis with 2-3 X 5000 i U of heparin-dihydroergotamine in order to reduce fatal pulmonary embolism in general surgery could be proven.
尽管物理方法被广泛应用，但直到1976年，基尔外科手术患者术后致命性肺栓塞的数量仍在增加。鉴于这些结果，1978年开始采用2 - 3×5000国际单位肝素 - 双氢麦角胺进行额外的全身预防。1979年至1983年间，经尸检证实的普通外科手术中致命性肺栓塞的发生率降至0.3%。应当指出的是，死于肺栓塞的9名患者中有6名还患有严重疾病。这是一个出色的结果，因为我们的研究还包括急诊手术后的高危患者，而卡卡尔和格鲁伯在他们的研究中并未纳入此类病例。通过对病历和相关尸检报告的广泛分析，证实了使用2 - 3×5000国际单位肝素 - 双氢麦角胺进行药物预防在降低普通外科手术中致命性肺栓塞方面具有很高的有效性。
