β-羟基丁酸对分离心肌细胞中底物氧化的调节作用。
Regulation of substrate oxidation in isolated myocardial cells by beta-hydroxybutyrate.
作者信息
Chen V, Wagner G, Spitzer J J
出版信息
Horm Metab Res. 1984 May;16(5):243-7. doi: 10.1055/s-2007-1014756.
The role of ketone bodies in myocardial substrate oxidation was examined using freshly isolated Ca2+-tolerant heart myocytes, beta-hydroxybutyrate (beta OHB) inhibited lactate oxidation by the myocytes by 30-60%, and the inhibition was concentration dependent. Palmitate oxidation was also markedly decreased, whereas octanoate oxidation was only minimally affected by the presence of beta OHB. Lactate, octanoate, or palmitate had little, if any, effect on beta OHB oxidation. beta OHB oxidation was reduced by 22-28% in myocytes isolated from chronically diabetic rats, whereas the oxidation of palmitate remained similar to the controls. However, beta OHB still inhibited palmitate oxidation to the same extent as in the control cells. Our data support the role of beta OHB as a physiologic regulator of myocardial substrate metabolism.
利用新鲜分离的耐钙心肌细胞研究了酮体在心肌底物氧化中的作用，β-羟基丁酸（β-OHB）使心肌细胞的乳酸氧化受到30%-60%的抑制，且该抑制作用呈浓度依赖性。棕榈酸氧化也显著降低，而辛酸氧化仅受到β-OHB存在的轻微影响。乳酸、辛酸或棕榈酸对β-OHB氧化几乎没有影响。从慢性糖尿病大鼠分离的心肌细胞中，β-OHB氧化降低了22%-28%，而棕榈酸氧化仍与对照组相似。然而，β-OHB对棕榈酸氧化的抑制程度仍与对照细胞相同。我们的数据支持β-OHB作为心肌底物代谢生理调节因子的作用。
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