Coloma J, Castell J V
Hoppe Seylers Z Physiol Chem. 1984 Apr;365(4):457-62. doi: 10.1515/bchm2.1984.365.1.457.
Liver regeneration after partial hepatectomy is characterized by an active phase of cell proliferation that is associated with a marked increase in thymidine kinase activity. Using non-denaturing gel electrophoresis and different substrate specificity, two isozymes could be detected. One was identified as the adult isozyme while the other was the fetal one. Both forms were present during liver regeneration. When the regenerative process was completed, the total enzymatic activity dropped to normal values and the fetal isozyme was displaced by the adult type.
部分肝切除术后的肝脏再生以细胞增殖的活跃阶段为特征，这与胸苷激酶活性的显著增加有关。利用非变性凝胶电泳和不同的底物特异性，可以检测到两种同工酶。一种被鉴定为成人同工酶，另一种是胎儿同工酶。在肝脏再生过程中两种形式都存在。当再生过程完成时，总酶活性降至正常值，胎儿同工酶被成人类型所取代。
