Mendenhall W M, Million R R, Bova F J
Int J Radiat Oncol Biol Phys. 1984 May;10(5):639-43. doi: 10.1016/0360-3016(84)90294-3.
This is a retrospective analysis of time-dose factors in 139 patients with 238 evaluable clinically positive lymph nodes treated with external beam radiation therapy alone to the primary lesion and neck for squamous cell carcinoma of the head and neck at the University of Florida from October 1964 through April 1980. Lymph node control by lymph node size was 8/8 (100%) for less than 1.0 cm, 51/62 (82%) for 1.0 cm, 68/82 (83%) for 1.5-2.0 cm, 24/40 (60%) for 2.5-3.0 cm, 24/38 (63%) for 3.5-6.0 cm, and 0/8 (0%) for greater than or equal to 7.0 cm. Lymph node control was also influenced by dose, overall treatment time, and fractionation schedule; these factors were interrelated and appeared to increase in importance as the size of the lymph node increased.
这是一项回顾性分析，研究对象为1964年10月至1980年4月在佛罗里达大学接受单纯外照射放疗治疗头颈部鳞状细胞癌原发灶及颈部的139例患者，共238个可评估的临床阳性淋巴结。根据淋巴结大小的淋巴结控制情况为：小于1.0 cm的为8/8（100%），1.0 cm的为51/62（82%），1.5 - 2.0 cm的为68/82（83%），2.5 - 3.0 cm的为24/40（60%），3.5 - 6.0 cm的为24/38（63%），大于或等于7.0 cm的为0/8（0%）。淋巴结控制还受剂量、总治疗时间和分割方案的影响；这些因素相互关联，且随着淋巴结尺寸的增加，其重要性似乎也在增加。
