Kwong E W, Huh S H, Nobler M P, Smith H S
Int J Radiat Oncol Biol Phys. 1984 May;10(5):665-70. doi: 10.1016/0360-3016(84)90298-0.
Sixty-five patients with prostatic adenocarcinoma Stages B and C were treated with intraoperative Iodine-125 prostatic implantation following bilateral pelvic lymphadenectomy. Pelvic nodal metastases were found in 31% of the patients: 23% (7/31) in clinical Stage B1 disease, 29% (8/28) in clinical Stage B2, and 83% (5/6) in clinical Stage C. All the patients have been followed for a period of 1 1/2 to 6 years. Serial digital rectal examination revealed complete regression of the palpable disease in 15% of the patients at 6 months, 47% at 1 year, and 87% at 2 years. Post-operative complications were also evaluated: 13% of the patients became sexually impotent, 11% had impaired potency after the procedure, and 16% of patients complained of dry ejaculation; and 17% developed scrotal and/or penile swelling, which persisted up to 14 months, but usually subsided within 5 months. Two patients developed local recurrence. Both patients responded to subsequent external radiation therapy of 7000 rad in 11 to 14 weeks with clinical regression of palpable disease.
65例B期和C期前列腺腺癌患者在双侧盆腔淋巴结清扫术后接受了术中碘-125前列腺植入治疗。31%的患者发现盆腔淋巴结转移：临床B1期疾病患者中为23%（7/31），临床B2期为29%（8/28），临床C期为83%（5/6）。所有患者均随访了1.5至6年。连续的直肠指检显示，6个月时15%的患者可触及疾病完全消退，1年时为47%，2年时为87%。还对术后并发症进行了评估：13%的患者出现性功能障碍，11%的患者术后性功能受损，16%的患者主诉射精困难；17%的患者出现阴囊和/或阴茎肿胀，持续长达14个月，但通常在5个月内消退。2例患者出现局部复发。两名患者均接受了后续11至14周内7000拉德的外照射治疗，可触及疾病临床消退。
