Trott K R
Int J Radiat Oncol Biol Phys. 1984 Jun;10(6):907-13. doi: 10.1016/0360-3016(84)90394-8.
After local irradiation of the heart or the recto-sigmoid of rats, chronic radiation damage develops after several months, leading to well-defined clinical syndromes of fatal pericarditis and myocardial necrosis or fatal ileus. In both organs, the LD-50 is below 20 Gy, and a pronounced split dose recovery has been measured with fractionated irradiation. In both organs, the primary radiation damage appears to be to the capillaries, which then leads to secondary parenchymal atrophy. Damage to structured vessels and fibrosis was only seen in areas of necrosis, which in the gut might be precipitated by secondary trauma to the atrophic mucosa.
对大鼠心脏或直肠乙状结肠进行局部照射后，数月后会出现慢性辐射损伤，导致明确的致命性心包炎和心肌坏死或致命性肠梗阻临床综合征。在这两个器官中，半数致死剂量（LD-50）低于20 Gy，并且已通过分次照射测量到明显的分次剂量恢复。在这两个器官中，原发性辐射损伤似乎主要发生在毛细血管，进而导致继发性实质萎缩。仅在坏死区域观察到结构性血管损伤和纤维化，在肠道中，萎缩黏膜的继发性创伤可能会促使这种情况发生。
