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吗啡、可乐定及强度变化对电击辨别力的影响。

Effects of morphine, clonidine, and intensity change on electric-shock discrimination.

作者信息

Genovese R F, Dykstra L A

出版信息

J Exp Anal Behav. 1984 May;41(3):309-17. doi: 10.1901/jeab.1984.41-309.

DOI:10.1901/jeab.1984.41-309
PMID:6736859
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1348061/
Abstract

The effects of morphine, clonidine, and changes in stimulus intensity were examined in squirrel monkeys responding on one of two levers following brief presentations of one of two electric-shock intensities (0.1 and 0.5 mA). Responses were designated as correct or incorrect depending on which shock intensity had been presented and which lever was pressed. Morphine (0.42 to 1.80 mg/kg) and clonidine (0.075 to 0.18 mg/kg) decreased percentage correct responding. Morphine and clonidine also increased response latency and the number of shock presentations that were not followed by responses. Changes in shock intensity also decreased percentage correct responding but had no effect on response latency or on the number of shock presentations not followed by responses.

摘要

在松鼠猴对两种强度电击(0.1毫安和0.5毫安)之一进行短暂呈现后,对两个杠杆之一做出反应的过程中,研究了吗啡、可乐定以及刺激强度变化的影响。根据呈现的电击强度以及按下的杠杆,将反应指定为正确或错误。吗啡(0.42至1.80毫克/千克)和可乐定(0.075至0.18毫克/千克)降低了正确反应的百分比。吗啡和可乐定还增加了反应潜伏期以及未引发反应的电击呈现次数。电击强度的变化也降低了正确反应的百分比,但对反应潜伏期或未引发反应的电击呈现次数没有影响。

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引用本文的文献

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本文引用的文献

1
Opiate withdrawal using clonidine. A safe, effective, and rapid nonopiate treatment.
JAMA. 1980 Jan 25;243(4):343-6.
2
Effects of morphine, levonantradol, and N-methyllevonantradol on shock intensity discrimination.吗啡、左那曲朵和N-甲基左那曲朵对休克强度辨别的影响。
J Clin Pharmacol. 1981 Aug-Sep;21(S1):341S-347S. doi: 10.1002/j.1552-4604.1981.tb02613.x.
3
Effectiveness of lofexidine in blocking morphine-withdrawal signs in the rat.洛非西定对阻断大鼠吗啡戒断症状的有效性。
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Opiate and opioid peptide effects on brain stem neurons: relevance to nociception and antinociceptive mechanisms.阿片类药物和阿片肽对脑干神经元的作用:与痛觉感受和抗痛机制的相关性。
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Clonidine analgesia and suppression of operant responding: dissociation of mechanism.可乐定镇痛与操作性反应抑制:机制的分离
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Drugs and visual perception: effects of LSD, morphine and chloropromazine on accuracy, bias and speed.药物与视觉感知:麦角酸二乙酰胺、吗啡和氯丙嗪对准确性、偏差和速度的影响。
Psychopharmacology (Berl). 1982;76(4):320-4. doi: 10.1007/BF00449118.
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Effects of morphine, d-amphetamine, and pentobarbital on shock and light discrimination performance in rats.吗啡、右旋苯丙胺和戊巴比妥对大鼠休克及光辨别能力的影响。
Psychopharmacology (Berl). 1980;70(2):213-7. doi: 10.1007/BF00435317.
8
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Psychopharmacology (Berl). 1980 Feb;67(2):155-63. doi: 10.1007/BF00431971.
9
Discrimination of electric shock: effects of some opioid and nonopioid drugs.电击辨别:某些阿片类和非阿片类药物的作用
J Pharmacol Exp Ther. 1980 May;213(2):234-40.
10
Nonparametric indexes for sensitivity and bias: computing formulas.敏感性和偏倚的非参数指标:计算公式
Psychol Bull. 1971 Jun;75(6):424-9. doi: 10.1037/h0031246.