吗啡、可乐定及强度变化对电击辨别力的影响。
Effects of morphine, clonidine, and intensity change on electric-shock discrimination.
作者信息
Genovese R F, Dykstra L A
出版信息
J Exp Anal Behav. 1984 May;41(3):309-17. doi: 10.1901/jeab.1984.41-309.
The effects of morphine, clonidine, and changes in stimulus intensity were examined in squirrel monkeys responding on one of two levers following brief presentations of one of two electric-shock intensities (0.1 and 0.5 mA). Responses were designated as correct or incorrect depending on which shock intensity had been presented and which lever was pressed. Morphine (0.42 to 1.80 mg/kg) and clonidine (0.075 to 0.18 mg/kg) decreased percentage correct responding. Morphine and clonidine also increased response latency and the number of shock presentations that were not followed by responses. Changes in shock intensity also decreased percentage correct responding but had no effect on response latency or on the number of shock presentations not followed by responses.
在松鼠猴对两种强度电击（0.1毫安和0.5毫安）之一进行短暂呈现后，对两个杠杆之一做出反应的过程中，研究了吗啡、可乐定以及刺激强度变化的影响。根据呈现的电击强度以及按下的杠杆，将反应指定为正确或错误。吗啡（0.42至1.80毫克/千克）和可乐定（0.075至0.18毫克/千克）降低了正确反应的百分比。吗啡和可乐定还增加了反应潜伏期以及未引发反应的电击呈现次数。电击强度的变化也降低了正确反应的百分比，但对反应潜伏期或未引发反应的电击呈现次数没有影响。
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