Ege G N, Elhakim T
J Clin Oncol. 1984 Jul;2(7):774-81. doi: 10.1200/JCO.1984.2.7.774.
The incidence, implications, and significance of an abnormal internal mammary lymphoscintigram (IML) in 981 breast carcinoma patients without histologic or clinical evidence of axillary metastases is reported. A 13%-16% incidence of parasternal abnormality in patients with early, operable disease correlates well with clinical data. The statistically significant increase, with P consistently less than or equal to 0.005, in incidence of local or distant relapse associated with an abnormal IML when compared to the normal IML emphasizes the value of the procedure as a marker. These results indicate that patients with negative axillae but an abnormal IML should be considered to have stage II disease and should be offered adjuvant therapy. The significance of the IML in determining the true extent of disease in patients with apparent local relapse as well as the prognostic implications of an abnormal IML in 311 patients seen initially with recurrent breast carcinoma is also reported.
报告了981例无腋窝转移组织学或临床证据的乳腺癌患者中异常内乳淋巴闪烁造影（IML）的发生率、影响及意义。早期可手术疾病患者胸骨旁异常发生率为13%-16%，与临床数据相关性良好。与正常IML相比，IML异常时局部或远处复发发生率有统计学意义的增加（P始终小于或等于0.005），强调了该检查作为一种标志物的价值。这些结果表明，腋窝阴性但IML异常的患者应被视为II期疾病，应给予辅助治疗。还报告了IML在确定明显局部复发患者疾病真实范围方面的意义，以及311例初诊为复发性乳腺癌患者中IML异常的预后影响。
