Lee L T
J Neurophysiol. 1984 Jun;51(6):1394-408. doi: 10.1152/jn.1984.51.6.1394.
In the siluroid teleost Ictalurus nebulosus, averaged evoked potentials and unit responses were recorded from various parts of the cerebellum following electrical stimulation applied to the telencephalon. Responses are most readily evoked in the cerebellum when area dorsalis pars centralis (Dc), a group of scattered large cells in the middle of the telencephalon, is stimulated. The configuration of the evoked field potentials differs according to the rate of stimulation. At a relatively low repetition rate, 0.5/s or lower, the response takes the shape of a positive wave, Pmol2, peaking at about 58 ms in the molecular layer. In the granular layer, the response is primarily a negative wave, Ngr1, followed by a slow positive deflection, Pgr3, with peak latencies of 52 and 130 ms, respectively. Ngr1 appears to be the result of summed mossy fiber-granule cell synaptic activations, with Pmol2 its concomitant passive source. No neuronal basis can be proposed for Pgr3. At higher rates of stimulation (greater than 2/S), the response to each shock is of longer latency and more complex. The stabilized waveform (i.e., after 5-9 cycles) is dominated by a surface-negative wave, Nmol, peaking at about 80 ms. The negative wave disappears at about 300 micron below the surface (slightly above the level where Purkinje cells are located) where it is replaced by a positive and negative sequence, P-Npur, peaking at about 80 and 160 ms, respectively. Both responses are bilaterally distributed but the ipsilateral responses are usually larger in amplitude and shorter in latency. Rostrocaudally, a latency gradient with longer rostral latencies is also found in both responses. To facilitate further comparative studies, the changes of peak latency and amplitude with stimulus strength of these two patterns of response were examined. Other dynamic characteristics of these two patterns of response were also examined and compared by stimulating with pairs and short trains of electric shocks. In discussing the functional implications of these findings, this telencephalocerebellar pathway appears to be a striocerebellar pathway.
在鲶形目硬骨鱼美洲鲶中，对端脑施加电刺激后，从小脑的各个部位记录平均诱发电位和单位反应。当刺激端脑中部一组分散的大细胞背侧中央区（Dc）时，小脑最容易诱发反应。诱发场电位的形态因刺激频率而异。在相对较低的重复频率，即0.5次/秒或更低时，反应呈现正波Pmol2的形态，在分子层中约58毫秒达到峰值。在颗粒层中，反应主要是负波Ngr1，随后是缓慢的正偏转Pgr3，峰值潜伏期分别为52毫秒和130毫秒。Ngr1似乎是苔藓纤维 - 颗粒细胞突触激活总和的结果，Pmol2是其伴随的无源信号。无法为Pgr3提出神经元基础。在较高的刺激频率（大于2次/秒）下，对每次电击的反应潜伏期更长且更复杂。稳定的波形（即5 - 9个周期后）以表面负波Nmol为主，约80毫秒达到峰值。负波在表面以下约300微米处（略高于浦肯野细胞所在水平）消失，被一个正负序列P - Npur取代，分别在约80毫秒和160毫秒达到峰值。两种反应均双侧分布，但同侧反应的幅度通常更大且潜伏期更短。在头尾方向上，两种反应中也都发现了头侧潜伏期较长的潜伏期梯度。为便于进一步的比较研究，研究了这两种反应模式的峰值潜伏期和幅度随刺激强度的变化。还通过成对和短串电刺激检查并比较了这两种反应模式的其他动态特征。在讨论这些发现的功能意义时，这条端脑 - 小脑通路似乎是一条纹状体 - 小脑通路。
