Bradley T J, Sauerman D M, Nayar J K
J Parasitol. 1984 Feb;70(1):82-8.
Early ultrastructural changes in the Malpighian tubules of the mosquito, Aedes taeniorhynchus, were examined following infection with the nematode, Dirofilaria immitis. After ingestion by the mosquito, the microfilariae enter the cells of the Malpighian tubules, becoming intracellular. During early development, the filarial prelarvae reside in the cell cytoplasm surrounded by a clear zone without a delimiting membrane. Cells infected with prelarvae differed from uninfected cells and from cells in uninfected mosquitoes in that the volume of the apical microvilli was reduced and mitochondria were retracted from these microvilli. Morphometric analysis was used to quantify the ultrastructural consequences of infection. In infected cells, microvillar volume, the percent of microvillar volume occupied by mitochondria, and volume of mitochondria within the microvilli were significantly reduced.
在用犬恶丝虫感染之后，对带喙伊蚊马尔皮基氏小管的早期超微结构变化进行了检查。被蚊子摄入后，微丝蚴进入马尔皮基氏小管的细胞，成为细胞内寄生虫。在早期发育过程中，丝状蚴前期幼虫位于被清晰区域包围的细胞质中，该区域没有界定膜。感染前期幼虫的细胞与未感染细胞以及未感染蚊子的细胞不同，在于顶端微绒毛的体积减小，并且线粒体从这些微绒毛缩回。形态计量分析用于量化感染的超微结构后果。在感染的细胞中，微绒毛体积、线粒体占据微绒毛体积的百分比以及微绒毛内的线粒体体积均显著减少。
