Ho N F
J Pharm Sci. 1984 May;73(5):600-3. doi: 10.1002/jps.2600730506.
This paper explores the physical model approach in studying the taste of drugs and assessing physical formulation factors for improving the undesirable taste of drugs. Various aspects of physiology relevant to the taste phenomenon have been reviewed to provide the biophysical basis for mathematical modeling. The model involves non-steady-state mass transport across the aqueous boundary layer and buildup of solute concentration at the essentially impermeable tongue surface. The theoretical predictions are consistent with experimental studies on the lag time to taste perception by the electrophysiological method and also with "instantaneous" psychophysical taste perception when solute concentrations much greater than the taste threshold are applied on the tongue. Within the framework of the non-steady-state model, novel experimental studies involving the use of a porous half-diffusion cell placed on the surface of an extended human tongue and the recording of the times for psychophysical taste response are proposed to quantify and provide mechanistic understanding of the taste of drugs and also physical formulation factors in overcoming undesirable taste properties.
本文探讨了物理模型方法在研究药物味道及评估改善药物不良味道的物理制剂因素方面的应用。对与味觉现象相关的生理学各个方面进行了综述，以提供数学建模的生物物理基础。该模型涉及穿过水相边界层的非稳态质量传输以及溶质在基本不可渗透的舌表面的浓度积累。理论预测与通过电生理方法对味觉感知滞后时间的实验研究一致，并且当溶质浓度远高于味觉阈值时应用于舌头时，也与“即时”心理物理学味觉感知一致。在非稳态模型的框架内，提出了新颖的实验研究，包括使用放置在延展的人舌表面的多孔半扩散池以及记录心理物理学味觉反应的时间，以量化并提供对药物味道以及克服不良味道特性的物理制剂因素的机理理解。
