液相色谱法测定亲脂性及其在一系列巴比妥酸盐同系物中的应用。
Liquid chromatographic determination of lipophilicity with application to a homologous series of barbiturates.
作者信息
Toon S, Mayer J, Rowland M
出版信息
J Pharm Sci. 1984 May;73(5):625-7. doi: 10.1002/jps.2600730511.
PMID:6737236
Abstract
A graphical method for determining the lipophilicity of the members of a homologous series of barbituric acids, from a consideration of their reverse-phase HPLC retention data, is described. The HPLC parameter used as the index of lipophilicity, RQ, is shown not only to form excellent correlations with the more commonly employed indices of lipophilicity, Rm and log P, but also to have a predictive capability for those log P values that had not previously been determined experimentally.
摘要
本文描述了一种通过考虑巴比妥酸同系物的反相高效液相色谱保留数据来确定其亲脂性的图形方法。用作亲脂性指标的高效液相色谱参数RQ不仅与更常用的亲脂性指标Rm和log P形成了良好的相关性，而且对那些以前未通过实验测定的log P值具有预测能力。
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