Sârbu C, Todor S
Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, Cluj-Napoca, Romania.
J Chromatogr A. 1998 Oct 2;822(2):263-9. doi: 10.1016/s0021-9673(98)00571-8.
The relative lipophilicity of ten non-steroidal anti-inflammatory agents have been determined by reversed-phase thin layer chromatography using different reversed-phase high-performance thin-layer chromatography plates and water-methanol mixtures as eluents. The compounds studied showed regular retention behavior, their RM values decreasing linearly with increasing concentration of methanol in the eluent. Principal component analysis allowed a more rational and objective estimation and comparison of lipophilicity determined by reversed-phase thin-layer chromatography. It also affords a useful graphical tool, since scatterplots of the scores onto the plane described by the first two components will have the effect of separating compounds from each other most effectively, thus obtaining "congeneric lipophilicity chart".
使用不同的反相高效薄层色谱板，以水 - 甲醇混合物作为洗脱剂，通过反相薄层色谱法测定了十种非甾体抗炎药的相对亲脂性。所研究的化合物表现出规则的保留行为，其RM值随洗脱剂中甲醇浓度的增加呈线性下降。主成分分析能够对反相薄层色谱法测定的亲脂性进行更合理、客观的估计和比较。它还提供了一种有用的图形工具，因为前两个成分所描述平面上得分的散点图将最有效地将化合物彼此分离，从而得到“同类亲脂性图表”。
