通过竞争性平衡透析法测定血浆中丙吡胺与α1-酸性糖蛋白的结合。
Binding of disopyramide to alpha 1-acid glycoprotein in plasma measured by competitive equilibrium dialysis.
作者信息
Norris R L, Ahokas J T, Ravenscroft P J, Henry M
出版信息
J Pharm Sci. 1984 Jun;73(6):824-6. doi: 10.1002/jps.2600730630.
PMID:6737271
Abstract
A modification of equilibrium dialysis in which alpha 1-acid glycoprotein and plasma compete directly for disopyramide has been used in conjunction with binding curves to measure the extent of the alpha 1-acid glycoprotein-disopyramide interaction. At concentrations in the therapeutic range, 80-90% of disopyramide was bound to alpha 1-acid glycoprotein for plasma from each of six healthy adults. Also, equilibrium dialysis data are presented, indicating that pH does not influence the binding of disopyramide within the therapeutic range.
摘要
一种平衡透析的改良方法，其中α1-酸性糖蛋白和血浆直接竞争地高辛，已与结合曲线结合使用，以测量α1-酸性糖蛋白-地高辛相互作用的程度。在治疗范围内的浓度下，来自六名健康成年人的血浆中80-90%的地高辛与α1-酸性糖蛋白结合。此外，还给出了平衡透析数据，表明pH在治疗范围内不影响地高辛的结合。
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Binding of disopyramide to alpha 1-acid glycoprotein in plasma measured by competitive equilibrium dialysis.通过竞争性平衡透析法测定血浆中丙吡胺与α1-酸性糖蛋白的结合。
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