胺碘酮的物理化学及分析特性
Physicochemical and analytical characteristics of amiodarone.
作者信息
Bonati M, Gaspari F, D'Aranno V, Benfenati E, Neyroz P, Galletti F, Tognoni G
出版信息
J Pharm Sci. 1984 Jun;73(6):829-31. doi: 10.1002/jps.2600730632.
PMID:6737273
Abstract
Data are reported on the analytical and physicochemical characteristics of amiodarone, for use in identifying and/or assaying this antiarrhythmic agent. The drug is highly soluble in chloroform and poorly soluble in water. Its acid-base constant (pKa) is 6.56, and its maximal lipid solubility range is from pH 3.5 to 5.5.
摘要
报告了用于鉴定和/或测定抗心律失常药物胺碘酮的分析和物理化学特性数据。该药物在氯仿中高度溶解，在水中溶解度低。其酸碱常数（pKa）为6.56，其最大脂溶性范围为pH 3.5至5.5。
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